More than 400 people took part in a charity run at Rother Valley Country Park for the charity Neurocare, which is based at the Royal Halamshire Hospital.
It was almost double last year’s attendance, and organisers hope to raise more than £11,500 to help finance equipment for brain surgery.
Families and friends, some in fancy dress, joined 5km and 10km runs last Sunday.
One of the largest teams was backing Chris Gregory, aged 34, of Birley, who has been training after battling benign then cancerous brain tumours.
He said: “I’d do anything for Neurocare. The charity helped me out when I was in hospital having operations and I’ve taken part in this for three years.”
Emma Douglas, Neurocare head of fundraising, said: “It was fantastic, with our best-ever turnout and an incredible atmosphere.”