They will be running, jogging, walking and even dancing in their thousands, women of all ages getting together for an important reason - raising money for vital cancer research.
The annual Race for Life returns to Sheffield this Sunday, but instead of following its traditional route around the city centre, this year the event is happening around Meadowhall shopping centre for the first time.
In 2012 4,755 women took part in the 5k race, raising more than £238,000 for Cancer Research UK - and at the last count, 3,815 women had signed up this year, with organisers hoping to collect £320,000.
There is still a chance to enter, too - people have until midnight tonight (Thursday) to register.
Hundreds of teams are running inspired by loved ones, including a group led by 28-year-old optician Danielle Hartley, whose fiancee Glen Cambell successfully fought testicular cancer.
Danielle has signed up along with female colleagues from Specsavers in Hillsborough, and PE teacher Glenn, 35, has taken on the role of official team coach, putting the ladies through their paces with regular training sessions.
Glenn was diagnosed in 2010 after finding a lump which was initially thought to be an infection, and underwent surgery and chemotherapy.
“I never guessed that cancer was going to come in to my life,” said Danielle.
“Thankfully Glenn didn’t hesitate in going to the doctor when he found the lump. Most of my colleagues in Sheffield have also been touched by cancer in some way.” The team hopes to raise £500.
Meanwhile the event’s organiser in Sheffield, Jenny Murgatroyd, said the race was a poignant reminder of her mum Andrea, who died of a brain tumour 11 years ago aged 42.
Jenny said: “All these fantastic women are helping mums of the future become grandmas, something my mum didn’t have the chance to do.
“Women come from different backgrounds and walks of life but they are united by their absolute determination to take on cancer and beat it.”
Runners heading for Meadowhall on Sunday will also be able to get a head start with extra early morning trams.
Supertram services will start from the Halfway terminus at 7.18am, 30 minutes earlier than normal. A later service leaves at 7.30am from Middlewood. Both trams will arrive more than an hour before the 9.30am start time.
To enter visit www.raceforlife.org or call 0845 600 6050.