Over 500 people took to the streets of Sheffield city centre to take part in the first national March on Cancer.
The city was one of 15 across the country taking part in the event organised by Cancer Research UK, and could become an annual event.
Marchers gathered in Tudor Square before setting off on a 45 minute circular route during which they were urged to shout and stamp their feet to show their determination that the disease can be conquered.
“It’s about fighting, it’s about surviving and it is also about empowerment,” said the charity’s area events manager Laura Taylor.
Among the marchers was former Star Superkid Niamh Hardy, 17, from Frecheville who was diagnosed with a stomach tumour two years ago.
“This is better than a day event - because it’s at night there’s a better atmosphere. It’s all very positive and upfront,” she said.
Claire Wilkins, 34, from Chesterfield, said she was marching for her dad Ken who had been battling bladder cancer for five years.
“I donate to this charity and I wanted to get involved. It’s not just been about dad, it’s been about the impact on the whole family,” she said.
“I’m pleased the event is so upbeat and positive.”