Lecturers at Sheffield College are planning strike action in a row over plans to axe up to 75 jobs.
A ballot of members of the University and College Union resulted in 86 per cent of those who voted backing a walk out, while 95 per cent supported action short of a strike.
An alternative to a full strike could see staff working strictly to contract and boycotting the systems being used by the college to target staff for redundancy.
Members of the union are due to meet next week to discuss their next moves and when any action might start.
Officials said the huge mandate for action meant the college now had to come back and negotiate seriously about job losses and its future plans.
The college says it is battling funding cuts of £4 million over two years and is seeking to become more self-sufficient by cutting costs.