Jagermeister will no longer be available to buy at Wetherspoons in Doncaster from later this month.
French brandies Courvoisier VS and Hennessy Fine de Cognac are also to be removed from drinks menu at all its pubs, including the Red Lion and Gate House.
They will be replaced with E&J Brandy (the number two selling brandy in the US), Black Bottle (the number one selling brandy in Australia) and Strika, a herbal liqueur produced in England.
Wetherspoons has already replaced Champagne with sparkling wines from the UK and Australia as well as German wheat beers with those from the UK.
Chairman Tim Martin, a strong supporter of Brexit, said: “The three new products will be offered at a lower price than those they are replacing.
“This is a significant move by us and highlights our commitment to offering an excellent range of UK and world products, with the emphasis on quality and value for the two million customers who visit our pubs each week.
“In blind tastings conducted by Wetherspoon, the new products were more popular than those they are replacing.
“Many commentators talk of a ‘cliff-edge’ if the UK ‘crashes out’ of the EU without a deal.
“In reality, there is no cliff-edge, only sunlit uplands beyond the EU’s protectionist system of quotas and tariffs.
“All EU products have UK or non-EU replacements, often at equal or better quality and price.”