Sheffield United boss Nigel Adkins was left to count the cost of progress to the second round of the FA Cup having made three enforced substitutions.
United saw off National League side Worcester City thank to a penalty from Jose Baxter and one each from Conor Sammon and Kieron Freeman.
However, three players picked up injuries and will have to be assessed before United take on Fleetwood in the Johnstone Paints Trophy on Tuesday night.
Che Adams, Chris Basham and Paul Coutts all came off and at this stage look unlikely to be available for the midweek tie.
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