There's a South Yorkshire derby at the AESSEAL New York Stadium kicking things off on Friday night.
And here, Chris Holt attempts to predict that, and the rest of the weekend's matches involving our sides.
Rotherham United v Sheffield Wednesday
With absolutely no disrespect intended to new boss Neil Redfearn, this match has lost its edge since Steve Evans surprisingly left the Millers. Evans loved taking on the Owls and became more than a sideshow in the run up to these games. Rotherham fans will probably welcome the concentration on football matters, however despite the positive signs since Redfearn took over, I'm going to go for an away win. That would, almost incredibly, see Wednesday stretch their unbeaten run to eight games in all competitions. Whatever the result, hopefully the match is as entertaining as the last between the sides. PREDICTION: Rotherham 1 Sheffield Wednesday 2
Sheffield United v Millwall
Sheffield United boss Nigel Adkins has already asked Blades fans to be patient during this one as the Blades take on a Millwall side who clearly haven't quite come to terms with League One football as yet, since dropping down from the Championship. The problem is the Lions could possibly be more at home coming to a venue like Bramall Lane. United haven't won consecutive league games since the end of August and I'm not convinced that, coming off the back of beating Fleetwood in midweek, they'll do it here either. PREDICTION: Sheffield United 1 Millwall 1
Barnsley v Fleetwood
Surely Barnsley's losing streak can't go on much longer...can it? It seems as though confidence may the main thing that's lacking at Oakwell and it could be that one win may spark things into life. Unfortunately, the Reds have a young squad and are already missing a couple of key men. Would a draw be enough to turn the tide? Perhaps. PREDICTION: Barnsley 1 Fleetwood 1
Peterborough v Doncaster Rovers
Darren Ferguson is probably glad to get this one out of the way early on. Going to your former club brings with it distractions but most of the talk has been about his early days at Rovers so there's been little in the way of a big build-up to this trip to Posh. A late winner in midweek brought a smile back to the faces of Rovers fans but they have to build on this now and push on up the table. While there's no way he'd say it publicly, Ferguson would love to win this one. I think his side will. PREDICTION: Peterborough 1 Doncaster Rovers 2
Chesterfield v Scunthorpe
A few weeks ago Chesterfield were struggling and Dean Saunders was beginning to have a fair amount of criticism thrown his way from frustrated Spireites. But two wins in a week took any, somewhat unwarranted, heat off and the comfort in which they saw off Southend on Tuesday, coupled with the clean sheet, changes things considerably. However, Scunthorpe's two defeats in their last five have come against the top two, Gillingham and Walsall, so the Iron will have no concerns about traveling to the Proact, and I'd back the visitors to pick up a point. PREDICTION: Chesterfield 2 Scunthorpe 2