Sheffield Wednesday slipped to their first defeat under head coach Carlos Carvalhal, losing 2-1 at Ipswich Town.
Ross Wallace claimed his first goal in Owls colours to put them ahead early on but strikes either side of half-time by Freddie Sears and Tommy Smith ensured they left Portman Road empty-handed.
To compound Wednesday's misery, Keiren Westwood may face a spell on the sidelines after being forced off with an injury.
It is the third year on the spin Ipswich have won this fixture by two goals to one, stretching their unbeaten run against the Owls to six.
Wednesday, who made one change from the team who started their opening-day victory over Bristol City, bringing in Lucas Joao for Atdhe Nuhiu up front, almost made a dream start in the fourth minute. Marco Matias, searching for his first goal in English football, latched on Jack Hunt's long punt, cutting infield on to his right football before unleashing a low shot which struck Bartosz Bialkowski's right hand upright.
Moments later, Wednesday switched off from a corner and were almost punished by Daryl Murphy. The Republic of Ireland international escaped his marker from Ainsley Maitland-Niles' corner but was denied by Keiren Westwood.
Owls number one Westwood then turned away Murphy's left foot curler before Jack Hunt made a vital block to prevent Ryan Fraser from having a sight at goal as the visitors continued to pile on the pressure.
Against the run of play, the visitors opened the scoring through Wallace, who slammed in his first Owls goal after Matias' cross turned shot was parried into his path by Bialkowski.
Wednesday's joy was short-lived as Freddie Sears capitalised on some hesitant defending by Glenn Loovens and Jeremy Helan to level things up.
It took an inch perfect challenge by Cole Skuse to stop the lively Matias from breaking clear after a great counter attack involving him and Joao.
Brimming with confidence, Sears fired tamely at Westwood after a surging run from deep as Ipswich continued to press.
Two minutes after the re-start, the Tractor Boys came close to getting their noses in front but Lewis McGugan, for the second weekend in a row, was in the right place at the right time to clear Christophe Berra's header off the line following Fraser's corner.
But Ipswich's pressure paid off in the 53rd minute when Smith pounced after Westwood could only parry Frazer's delivery.
Things shortly went from bad to worse when Westwood was forced off with a knock, meaning a first Championship outing for Joe Wildsmith.
It wasn't long before the academy graduate was in the thick of the action, producing a smart save to deny the impressive Sears.
Wednesday threw on Nuhiu to give Joao extra support in the final third but Ipswich carried the greater attacking threat.
Wallace's cross was pushed over by Bialkowski following a fine counter attack as the Owls looked to stretch Ipswich's backline.
In truth, Ipswich could have won by more had they shown more composure in the final third, with Berra seeing his header cleared off the line by Wednesday substitute Kieran Lee in the dying minutes.
Joao tried his luck from distance only to be foiled by Bialkowski as Ipswich deservedly held on for maximum points.