Back in the 60s, the city had Joe Cocker performing at the legendary Woodstock festival. Then there was the city's electro-pop pioneers and the rock of Def Leppard. And today, Arctic Monkeys, from High Green, are among the biggest names in music.
Some have hit the heights of scoring a UK number one hit, while others have earned cult followings or dedicated support locally.
We asked our readers to tell us the best song ever released by a Sheffield band with hundreds getting back to us with their suggestions. Sadly, some that were mentioned have been left out due to the sheer quantity.
We have counted the totals for the most frequent suggestions, to rank the top choices, and although the number one chosen from our readers' suggestions may not be your favourite, you're sure to have heard it, along with most of the western world!
Take a look at the list below, and see how many you agree with. We have listed songs in reverse order, as a countdown, with the readers' number one choice last on the list.
1. The 14 best ever songs by Sheffield acts
These are the 26 best songs from Sheffield artists - according our to readers. They're in reverse order. PIctures: National World / PA Photo: National World / PA
2. Heavyweight Champion of the World (Reverend and the Makers)
Heavyweight Champion of the World, by Reverend and the Makers, received a nomination. Picture:: Zak Hussein/PA Wire Photo: Zak Hussein
3. I Bet That You Look Good On The Dancefloor (Arctic Monkeys)
Arctic Monkeys received a nomination for I Bet That You Look Good On The Dancefloor Photo: Chris Etchells
4. Follow You (Bring Me The Horizon)
Bring me the Horizon received a nomination for Follow You. Picture Scott Merrylees Photo: Scott Merrylees