Here we take a look back at the previous nine clashes between the two sides.
5. February 2017, Wednesday 1-2 Brentford
Goalscorer Fernando Forestieri gets away from Brentford's Harlee Dean in Wednesday's 2-1 defeat at Hillsborough in February 2017. Forestieri netted a 90th minute consolation after John Egan and Dean had given the Bees a two-goal lead. Photo: Steve Ellis
6. August 2016, Brentford 1-1 Wednesday
Sam Hutchinson screams with delight after scoring a last-gasp equaliser in the Owls' 1-1 draw at Griffin Park in August 2016. Photo: Freelance
7. February 2016, Wednesday 4-0 Brentford
Lucas Joao celebrates netting the fourth Wednesday goal with Jose Semedo in a 4-0 win at Hillsborough in February 2016. Photo: Steve Ellis
8. September 2015, Brentford 1-2 Wednesday
Atdhe Nuhiu celebrates netting his penalty in the 2-1 win at Griffin Park in September 2015. Lucas João was also on target in the victory. Photo: Steve Ellis