Garry Monk's side begin the 2020/21 campaign in tough circumstances after being charged by the EFL in July – resulting in a points deduction.
But do the bookies believe Wednesday can avoid relegation? Scroll and click through the pages to find out:
21. Luton Town
Odds to be relegated from the Championship: 7/2 Photo: Pete Norton
22. Rotherham United
Odds to be relegated from the Championship: 2/1 Photo: George Wood
23. Sheffield Wednesday
Odds to be relegated from the Championship: 13/8 Photo: Michael Steele
24. Wycombe Wanderers
Odds to be relegated from the Championship: 1/2 Photo: Alex Burstow