Garry Monk's side begin the 2020/21 campaign in tough circumstances after being charged by the EFL in July – resulting in a points deduction.
But do the bookies believe Wednesday can avoid relegation? Scroll and click through the pages to find out:
5. Bournemouth
Odds to be relegated from the Championship: 22/1 Photo: Clive Brunskill
6. Stoke City
Odds to be relegated from the Championship: 20/1 Photo: David Rogers
7. Cardiff City
Odds to be relegated from the Championship: 20/1 Photo: Clive Brunskill
8. Swansea City
Odds to be relegated from the Championship: 16/1 Photo: Naomi Baker